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The activation of ferroptosis in psoriatic lesions has been observed, with decreased expression of GPX4 and increased levels of lipid peroxidation markers, such as 4-HNE (199)

Phase 2 trials showed up to 24% body weight reduction at the highest dose, and Phase 3 data from the TRIUMPH program pushed that number even higher, reaching 28.7% in participants with obesity and knee osteoarthritis