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Polyphenols frequently exhibit limited absorption rates and undergo rapid metabolism within the human body, hence constraining their capacity to reach and exert their effects on specific regions within the brain ( in vitro and animal models to clinical practice has been difficult due to the lack of replication of identified effects in human studies

the key to properly identify them is the recognition of abnormal sleep-wake patterns using sleep diaries beyond the complaint of insomnia or daytime sleepiness (93)

Moreover, arsenic treatment inhibited IRS1 and Akt phosphorylation and induced ectopic fat accumulation in the muscle fibers (106), which are markers of insulin resistance in muscle (100)

doi: 10.3389/fendo.2022.972115 16 Hamilton-WilliamsEELorcaGLNorrisJMDunneJL