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Bile acids also possess strong microbial activity and serve as signaling molecules, acting as ligands for nuclear receptors, thereby impacting various metabolic processes (192)

(2022) 14:e22464

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Recently, it was shown with the use of knockout mice for Cdkn2a/2b and/or Pten that DNA double-stranded breaks cooperate with the loss of Ink4 and Arf (protein products from Cdkn2a/2b after alternative splicing) tumor suppressors to generate glioblastomas with frequent c-Met amplification (Camacho et al., Table 2 Human carcinogenesis associated with iron overload