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4.2.2 NAM-competitive inhibitors NAM-competitive inhibitors are substances that can compete with the substrate NAM for the binding site in NNMT

Activity was monitored via quantification of radiolabeled reaction product histone [methyl- 3 H]-L-arginine

Food and Drug Administration approved it as Mounjaro for type 2 diabetes in 2022 and as Zepbound for chronic weight management in 2023, and it is authorized by the European Medicines Agency as well