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The role of AOs in regulating the activity of cell signaling pathways has been demonstrated by the discovery of close links between AOs and ROS signaling in the stress response, growth, and development of cotton (Li et al., 2007, 2017

However, in the United States, lacking definite data about susceptibility to clarithromycin, metronidazole, and levofloxacin, we should assume resistance is present and use a 4-drug regimen (eg, concomitant therapy or bismuth quadruple therapy)

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