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Pre-treatment with allopurinol (a xanthine oxidase inhibitor) or dimethyl sulfoxide (DMSO) (a hydroxyl free radical scavenger) can block the apoptotic activity induced by smoking, and does not affect the p53 level of the mucosa (26), suggesting that the apoptosis induced by cigarette smoking is mediated through reactive oxygen species (ROS) and occurs independently of the p53 pathway

Hookah smoking is typically done in groups, with the same mouthpiece passed from person to person

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Rather, its emphasis is on the thoughts, feelings, physical sensations, and behaviors the patient has learned to associate with the condition they are battling