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Given that fibrotic plaque is similar to mechanical abnormal structure, the appropriate micro-trauma by the injection may be beneficial to plaque remodeling and treatment similar to operative resection ( Verapamil As a calcium channel blocker used in the treatment of hypertension, verapamil plays an anti-fibrotic role by blocking the transportation of calcium into fibroblasts, inhibiting the transfer of proline into the matrix and stimulating the phenotype transformation of fibroblasts to produce collagenase (Shirazi et al., 2009)

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Schisandra chinensis (Turcz.) Baill, isolated from Schisandra chinensis polysaccharides (SCP), and preventative electroacupuncture can regulate gut microbiota by increasing the proportion of beneficial bacteria, thereby suppressing harmful bacteria and reducing TMAO production (He et al., 2021