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310 The mechanisms by which hyperuricemia contributes to chronic kidney disease include renal inflammation, endothelial dysfunction, and activation of the renin-angiotensin system

Lpez de las Hazas M-C, et al

Nat Rev Clin Oncol 11 , 365376 (2014)

The risk of developing melanoma over a CMN is believed to be directly proportional to the size of the nevus and varies from 2.6 to 4.9% for small and medium nevi and from 6 to 20% for giant nevi [6]