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Long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study

PubMed Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, Zhang J, Pho NH, Walker SR, Winckler W, Getz G, Frank D, Hahn WC, Eck MJ, Mani DR, Jaffe JD, Carr SA, Wong KK, Meyerson M

Although no randomized trials exist, the uniformity of observational data has led GeneReviews and European neurometabolic taskforces to issue class I recommendations for immediate high-dose riboflavin upon molecular diagnosis (14)

Stimulation of -cells with fructose, sucralose or non-caloric sweeteners led to increased insulin blood levels (Nakagawa et al., 2009), an effect blocked by knocking out T1R3 or inhibiting it with gurmarin, suggesting T1R3 functionality in -cells (Geraedts et al., 2012