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Animal models help to understand the complex interplay between the different cell types of the CNS and uncover general mechanisms of damage and repair of myelin sheaths

However, following a stroke, the rapid onset of oxygen and glucose deprivation leads to endothelial cell dysfunction, degradation of tight junction proteins (such as claudins and occludins), and activation of matrix metalloproteinases (MMPs), particularly MMP-9 (73, 74)

LZ: Data curation, Writingoriginal draft

Methods: We extracted data concerning SNP variants in GLP1R and liver disease diagnoses, analyzing these in relation to metabolic, hepatic, and clinical phenotypes using the Penn Medicine Biobank, UK Biobank, and All of Us database