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A previous study reported that vitamin C could prevent monosodium iodoacetate (MIA) induced changes such as cell growth inhibiting and oxidative stress increasing, apoptosis, MMPs increasing, and proteoglycan loss in a chondrosarcoma cell line (SW1353) [160]

This work is supported, in part, by National Institutes of Health grants R01CA291876, R01CA284108, R01NS117828 and T32-CA196561-08, American Cancer Society grant RSG-22-052-01-IBCD, Cancer Prevention and Research Institute of Texas grants RP240493 and RP250191, the American Brain Tumor Association, the Radiological Society of North America, the Red Gates Foundation and Colorectal Cancer Alliance

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