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For example, certain polyphenols or quinones can aggregate proteins or generate assay-reactive species, giving an illusion of activity in screening tests

Many tools have been developed and employed in the structural biology community to enhance the crystallizability of proteins, including in situ proteolysis 6,7,8 , lysine methylation 9,10,11 , surface entropy reduction 12,13,14 , metal mediated crystallization 15 , polymer-driven crystallization 16 , site-specific mutagenesis 17 , and chaperone-aided crystallization (also see recent reviews refs 18,19)