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Pegvisomant increases the metabolic rate of food-deprived mice To assess whether the energy-conserving effects of GH can be pharmacologically manipulated, we tested in mice the effects of a clinically available GHR antagonist (pegvisomant)

Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model