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Description

The patients were provided with written information indicating the nature and goals of the study and signed an informed consent form

All AgNP preparation trials were conducted three times for reproducibility, and values were expressed as mean standard deviation

B = G or T or C

Discovery of 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a potent and selective estrogen receptor degrader (SERD) for the treatment of estrogen-receptor-positive breast cancer