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In chemical synthesis, Se in the +4 valence state (e.g., selenite, selenite, or SeO 2 ) is commonly used as a precursor, while reducing agents (e.g., ascorbic acid and glutathione [GSH]) and stabilizers (e.g., chitosan and pectin) are used for the formation and maintenance of SeNPs (244, 245)

It supports the nervous system by aiding in the formation of myelin, which protects nerve fibres, and it plays a key role in energy production through its involvement in the breakdown of nutrients into usable energy

Arachidonic acid oxygenation by COX-1 and COX-2

Importantly, we observed that Grx1 overexpression significantly reduces both soluble and insoluble TDP-43 levels