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178,179 Additionally, cAMP can activate Rap1 through EPAC (Exchange Protein directly Activated by cAMP), 180,181,182 which is involved in regulating insulin secretion

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Proteases may deeply influence the integrity of the IEB either through excessive proteolysis determined by direct cleavage of intercellular junction proteins, or by a functional TJ opening elicited by the activation of protease-activated receptors (216)