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And some of them, like formaldehyde, are cancer-causing

Frederick Jackson Turner, The Significance of the Frontier in American History, in Annual Report of the American Historical Association for the Year 1893 (Washington, DC: Government Printing Office, 1894), 200

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Thus, we propose that the way forward for the study of arsenic tolerance will involve more extensive demographic modeling, large-scale simulation studies to identify statistics that may be useful for identifying patterns associated with genetic hitchhiking/polygenic adaptation within the context of the inferred population history, and finally an examination of the correspondence between large-scale association studies and genomic scans in order to identify top candidate loci