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Exclusion criteria were the following: any known systemic infection or disease, pregnancy or lactation, alcoholism, tobacco smoking, use of antibiotics, antioxidants (e.g., vitamins C, E) or anti-inflammatory drugs within the last 6 months, periodontal disease, presence of an oral mucosal inflammatory condition (e.g

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Gut microbiota modulation The GI tract hosts a dense and diverse community of microorganisms that play a critical role in maintaining digestive health, regulating immunity, synthesizing vitamins, metabolizing indigestible substrates, and maintaining the mucosal barrier

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