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Description

Although the half-life is sometimes quoted as being approximately 7-42 hours, there is actually no fixed half-life

at P7) compared with P15 (t.i

Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice