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10.1016/j.phymed.2020.153398 239 YanT.ZhuX.ZhangX.JiaX.LiuJ.WangX.et al (2022)

Below this threshold, many peptides can achieve meaningful sublingual bioavailability

However, there was a negative correlation of RBC glutathione with excretion of mercury at the 9th dose (r = -0.27), which suggests that mercury has an adverse effect on RBC glutathione, presumably by both causing it to be excreted from the body after the glutathione binds to mercury, and perhaps more importantly by inhibiting production of glutathione

Patients with a history of severe cutaneous or other serious delayed-type reaction (e.g., drug reaction with eosinophilia and systemic symptoms or Stevens-Johnson syndrome) to an antimicrobial sulfonamide should be cautioned to maintain lifelong avoidance