glutathione trapping reactive metabolites

glutathione trapping reactive metabolites of drug produced by biomimetic metalloporphyrin catalysts - Lassila - 2015 - Rapid Communications in Mass Spectrometry Reactive Metabolite Factsheet - Evotec

Name: glutathione trapping reactive metabolites of drug produced by biomimetic metalloporphyrin catalysts - Lassila - 2015 - Rapid Communications in Mass Spectrometry Reactive Metabolite Factsheet - Evotec
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Reactive Metabolite Factsheet Evotec Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms Glutathione Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Mitigation of reactive metabolite formation for a series of 3 amino 2 pyridone inhibitors of Bruton's tyrosine kinase (BTK) ScienceDirect

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Description

To determine how APR-246 depletes GSH, we applied mass spectrometry to show that 2-methylenequinuclidin-3-one (MQ), the active component of APR-246, reacts with GSH inside cancer cells (Fig