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Abbreviations 5Bs: Bioavailability, Biopersistence, Bioprocessing, Biomodification, and Bioclearance (of nanoparticles) ABB: Air-Blood-Barrier AM: Alveolar Macrophages AuNP: Gold NanoParticle BAL: BronchoAlveolar Lavage BALT: Bronchus-Associated Lymphoid Tissue BaP: Benzo-a-Pyrene BMD: BenchMark Dose BSA: Bovine Serum Albumin CNS: Central Nervous System CPC: Condensation Particle Counter EC: Elemental Carbon EC1: Epithelial type 1 Cells EC2: Epithelial type 2 Cells EELS: Electron energy-loss spectroscopy EPR: Enhanced permeability and retention GIT: Gastro-intestinal-tract HEC: Human Equivalent Concentration HRTEM: High Resolution Transmission Electron Microscopy ID: Initial Dose IM: Interstitial Macrophages IrNP: Iridium NanoParticle IT: IntraTracheal LOAEL: Lowest Observed Adverse Effect Levels LT-MC: Long-Term Macrophage-mediated Clearance MCC: MucoCiliary Clearance MCNs: MiCellar Nanocomplexes MPPD: Multiple Path Particle Dosimetry N-N: Normal to Normal heart beat rate NOAEC: No Observed Adverse Effect Concentration NOAELs: No Observed Adverse Effect Levels NOM: Natural Organic Matter NP(s): NanoParticle(s) OPC: Optical Particle Counter PEGylation: Modification of (often medical) particle surfaces with PolyEthylene Glycol PM: Particulate Matter PM10: PM smaller than 10 m PM2.5: PM smaller than 2.5 m PSL: PolyStyrene Latex RR50: the frequency of beat to beat heart intervals fluctuating by more than 50 msec SEM: Scanning Electron Microscopy SP-A: Surfactant Protein A SP-D: Surfactant Protein D sp-ICP-MS: single particle Induction Coupled Mass Spectrometry STEM: Scanning Transmission Electron Microscopy TEM: Transmission Electron Microscopy TiO2-NP: Titanium dioxide NanoParticle UFP: UltraFine Particles UICC: Union for International Cancer Control References GBD 2015 Risk Factors Collaborators