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More recent DSIP and DSIP-analogue research, involving modified compounds designed to behave similarly to DSIP, has explored possible neuroprotective and stroke-recovery roles in animal models, but this work remains preclinical rather than validated through large human therapeutic trials [1112][1819]

Abbreviations AA: Ascorbate APX: Ascorbate peroxidase CAT: Catalase DHA: Dehydroascorbate DHAR: Dehydroascorbate reductase GR: Glutathione reductase GSH: Reduced glutathione GSSG: Oxidized glutathione MDHAR: Monodehydroascorbate reductase O 2 : Superoxide anion radical OH: Hydroxyl radical ROS: Reactive oxygen species SOD: Superoxide dismutase TFs: Transcription factors References Abdel-Ghany SE, Mller-Moul P, Niyogi KK, Pilon M, Shikanai T (2005) Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts

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