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And, while we've had a deterioration in our lifestyle over the past 40 years, a pretty precipitated and accelerated, sort of, move in the wrong direction on that, it's been largely offset by pretty amazing medical advances

Mov Disord (2010) 25(15):26216

Unlike HSCs, which divide and differentiate at a much slower rate and can rely on glycolysis and the limited OXPHOS possible in the bone marrow niche for their energy needs (10), LSCs divide more rapidly, generating a higher energetic demand compared to HSCs