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therefore, the use of BCL-2 inhibitors has recently emerged, especially the use of venetoclax in the treatment of AML ( in vivo , factors such as the upregulation of fatty acid oxidation (FAO) (Stevens et al., 2020), mutations in BCL-2, overexpression of the anti-apoptotic proteins MCL1 or B-cell lymphoma extra-large (Bcl-xL) (Saliba et al., 2021), or the OPA1 (Mitochondrial Dynamin Like GTPase) fusion protein have been described as mediators of resistance to venetoclax ( The enzymes isocitrate dehydrogenases (IDH) produce NADPH by metabolizing isocitrate to -ketoglutarate (-KG), which is an important factor in the TCA cycle

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EC-covered beads were embedded into the collagen gel and then DMEM supplemented with 2% FBS with a range of concentrations (0.37, 0.55 and 0.74 M) of VGB4 or (0.74 M) scr in the presence of (200 ng/ml) VEGF-A were added on top of the collagen gel