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If the nerve is stimulated, for example by a disk herniation at L4 level through the inflammatory pathways that are triggered during discal degeneration, the impulses run along the paravertebral sympathetic trunk and they can reach the upper lumbar sensory nerve roots, such as L1 or L2, passing by the white rami communicants [20]

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2c,d) may be due to stromal cells which include endothelial cells, pericytes, cancer-associated fibroblasts, and tumor infiltrated lymphocytes rather than cancer cells

While FOXO4-DRI is designed to target senescent cells, the intricate crosstalk within biological systems means broader effects are always a possibility