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When MPTP damages nigral dopaminergic neurons, the cellular debris and inflammatory mediators released by these neurons can further activate microglia, leading to a substantial release of inflammatory factors and the formation of a self-reinforcing vicious cycle

(1213) Panza, F

Microarray analysis has shown that de novo CNVs occur at a significantly higher rate in sporadic cases of autism as compared to the rate in their typically developing siblings and unrelated controls