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The first is the basis for LifeVantage's claim on its website that Protandim is " the only supplement clinically proven to reduce oxidative stress in humans by an average of 40 percent in 30 days ." In the study, which was not double-blind nor placebo-controlled, 29 healthy men and women took one caplet of Protandim (675 mg of its proprietary blend) daily for 4 months (Nelson, Free Radic Biol Med 2006)

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Under pathological conditions, ROS in cells may transmit redox signals through the reversible oxidation of signaling molecules, resulting in permanent changes in inflammatory gene expression [9]