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Your exact treatment plan depends on: the severity of your melasma your skin type how your skin responds how consistent you are with sun protection and skincare Maintenance treatments may also be recommended to help keep results on track

Macrophages play an important role in inflammatory events and promote the transcription of pro-inflammatory mediators

Astrocytes are essential for the metabolism of the brain, transporting multiple nutrients and metabolic precursors to the neurons by the malate-asparte shuttle and other transporters [24]

SCFAs constitutes a direct linkage between gut microbiome and immune system due to their capability for inducting regulatory T-cells (Treg) [72] and regulating Tregs and Th17 balance [73]