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Metformin , the first-line drug treatment for type 2 diabetes, lowers elevated blood glucose in part by suppressing gluconeogenesis in the liver (McIntosh 2011

Model building and refinement The initial structure model of hTauT was computationally generated using AlphaFold3 (AlphaFold Protein Structure Database, #AF-P31641-F1) 58 and then fitted into the cryo-EM map using UCSF Chimera X 59 and rebuilt manually using Coot 60