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For the image analysis and western blotting results, significant differences between different groups were tested with two-tailed ANOVA if no between-subject effect was considered, followed by a two-tailed Tukey multiple comparison test

These CoNPs can be first accumulated around the implant to cause adverse local reactions and then enter into the blood vessels followed by reaching the liver, heart, brain, kidney, and other organs through systematic circulation, which leads to multi-system toxicity symptoms

The study population includes patients with ESLD with a recent episode of decompensation and/or patients with hepatocellular carcinoma, all with a prognosis of greater than 3 months