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To investigate this question, we varied the amino acid input (cysteine, glycine, glutamate, methionine, and serine) throughout the day and used the model to compute the time courses of all the concentrations in the model, and all the velocities

Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]

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ALOX12 specifically interacts with SLC7A11, to some extent also showing that p53 targeting of SLC7A11 induces ferroptosis dependent on ALOX12