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Carvings at the top of the posts represent the hole in a needle to indicate an Ainu woman is buried there, or a spear point to represent the burial site of a man

PMID 3399075

What matters next: Efficacy and tolerability (GI burden, discontinuation) Durability of weight loss and body-composition preservation Cardiometabolic outcomes (CV, NAFLD/NASH, T2D remission) Oral availability and simplified dosing Access & affordability with value-based contracts Exciting sciencenow the challenge is pairing it with outcomes evidence and sustainable coverage so more people benefit

It could also be further improved by the inclusion of biological factors involved in material degradation in vivo, such as enzymatic activity, microbial colonization, or changes in saliva pH