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35,39,40,41 Above evidence indicates the crosstalk between BMAL1 and the hypoxic microenvironment in modulating bone regeneration, though the specific regulatory mechanism remains unclear

Statements Author contributions ZM: data collection and writing the manuscript

10 Polycystic ovary syndrome (PCOS) , a condition characterized by excess androgen (male hormone) production, ovarian structural and functional abnormalities, and metabolic disturbance, is a common hormonal cause of infertility