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In one of the most extensive clinical studies across Europe (DO-HEALTH), supplementation of vitamin D, omega-3, and home-based exercise reduced prefrailty by 39% 95 and incident invasive cancer by 61% 96 over a 3-year follow-up

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PDI is S-nitrosylated in lumbar spinal cords of sporadic ALS patients (Walker et al., 2010), which abrogates PDI-mediated attenuation of neuronal cell death triggered by ER stress or misfolded proteins (Uehara et al., 2006)

However, the detection window depends heavily on which metabolites are targeted