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Oxidative eustress: the physiological role of oxidants

Cells are exposed to oxidative stress under conditions such as nutrient starvation (or oversupply) and catabolic stress such as surgery, sepsis or infection, but also during cell proliferation (Reference Cruzat, Pantaleao and Donato7,Reference Cruzat, Keane and Scheinpflug12)

In mouse models of pancreatic cancer, ivosidenib prevented tumour growth, and this was reversed by oral glucose supplementation 171