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After discarding the supernatant, islets were incubated in KRBH containing 0.1% BSA, 1 mM glucose and indicated concentrations of somatostatin (SST-14) or insulin at 37 C for 1 h

Conversely, the human body has natural antioxidant systems, which include an enzymatic antioxidant system comprising superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), among others ( 2 Molecular mechanism of oxidative stress 2.1 Reactive oxygen species ROS encompass O 2 - , OH , and H 2 O 2

After checking the quality of the samples (FastQC, v.0.11.7), the files were mapped to the mouse genome (Genome build GRCm38) downloaded from Ensembl using the star aligner (Dobin et al, 2013), version 2.7.4a

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