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Azami SH, et al

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PCA enhances the activity of intracellular antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), promoting the clearance of ROS and alleviating oxidative stress in cells (Figure 4) (Laskar and Mazumder, 2020)

Even more, it has recently been postulated that the restriction of DNA synthesis to the reductive phase of the cycle in yeast may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication [51], which implies the common mechanism of the DNA protection during S phase in all eukaryotes