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Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity

Suppression of ODC1 activity appears to redirect ornithine metabolism toward urea production rather than putrescine, and because urea can be efficiently eliminated from astrocytes via the bloodstream and excreted in urine, no adverse effects were observed under the reported treatment regimen

The successful wet-laboratory experiment was thus the proof of concept of the model (Gajdanowicz et al., Reference Gajdanowicz, Michard, Sandmann, Rocha, Corra, Ramrez-Aguilar, Gomez-Porras, Gonzlez, Thibaud, van Dongen and Dreyer2011

Many patients experience moderate to severe pain, often described as stabbing or burning, which can persist for years after treatment cessation, significantly impairing their quality of life (Michalova et al., 2023