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doi: 10.1016/j.ejphar.2016.02.038

It is important to recognize that these reports are anecdotal and not substantiated by large scale clinical trials

Reactive oxygen species (ROS) can induce a myriad of pathophysiological events, including the synthesis and release of inflammatory cytokines, compromising the integrity of the blood-brain barrier, and with more pronounced changes causing widespread pathological changes, including cerebral perfusion, ischemia and edema (Mendes Arent et al., 2014

Skoulidis F, Goldberg ME, Greenawalt DM, Hellmann MD, Awad MM, Gainor JF, Schrock AB, Hartmaier RJ, Trabucco SE, Gay L, et al