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43 ChenS.BinP.RenW.GaoW.LiuG.YinJ.et al (2017)

Crosstalk of reactive oxygen species and NF-kappaB signaling

So the answer is no, not every client has a histamine issue

In general, nanomaterials smaller than 20 nm tend to accumulate in the kidney, whereas nanomaterials 20 100 nm in size are preferentially deposited in the liver [232]