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It has also been referenced in the Axis of Awesome's song medley "Four Chord Song", a reference to the fact that the chord progression in "Cigarettes Will Kill You" is similar to that of Journey's "Don't Stop Believin'" and Toto's "Africa"

This is categorized into open and closed systems, offering a variety of flavors such as tobacco, fruit, beverages, sweets, and others

Essentially, just like chocolate or alcohol, too much of a good thing can make you momentarily sick but that doesnt mean youve ODed

This is one of the reasons that so many people overuse without realizing, and why its so easy to get nic sick or dependent