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Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)

In vitro experiments demonstrated that quercetin could maintain cell morphology in both Huh7 and Huh7 R cell lines and decrease the number of HCC cell clones, indicating its inhibitory effect on HCC cell growth

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However, GSNOR activity was induced by high temperature during early hours of stress imposition (Figure 1)