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These targets are located in the traditional organs, comprised of the liver, fat, muscle and pancreatic islet, and more recently the non-traditional targets, including the intestine, kidney, brain, macrophage and adrenal gland (Fig

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Oxidative metabolism of incubated cerebral cortex slices from pyridoxine-deficient kittens

Notably, M1 macrophages are more resistant to ferroptosis than M2 macrophages, largely because of elevated levels of inducible nitric oxide synthase (iNOS) (Kapralov 2020)