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Loading phase uses higher doses (2.5-5mg) 2x weekly for 4-6 weeks to rapidly saturate tissues and initiate healing

This is especially important for compounded or injectable preparations

Apigenin shows progesterone receptor B modulatory activity

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death