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Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

B12 is absorbed well from the fatty layer, so the vitamin reaches the bloodstream either way

While the assumption of no intercurrent events is often not entirely realistic, this estimate is the closest we can currently get to an estimate of the true pharmacological effect of the drug and is referred to as the trial product estimate