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Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)

Two HAMA subdomain scores were calculated: (a) anxiety HAMA symptoms, which were defined as anxious mood + tension + fears + anxiety behavior during the interview

(2017) suggested that hydrogen peroxide-inducible clone-5 (Hic-5) may be crucial for c-Met signaling pathways and HCC metastasis because it mediates HGF-induced reactive oxygen species (ROS)-JNK-signaling pathways in HCC (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients

Possible confounding factors in patients include co-existing pathologies and treatments, lack of selection of treatments according to ROS levels, among others