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This inhibitory activity of luteolin on the LPS-induced production of IL-6 can be attributed to its ability to inhibit the both JNK signaling pathway and the activation of AP1 in the microglia (Jang et al., 2008)

New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases

The excessive activation of mitophagy may lead to the unnecessary removal of healthy mitochondria, triggering cellular energy depletion, while insufficient inhibition of mitophagy fails to eliminate dysfunctional mitochondria, allowing dysfunction to persist

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