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One of the mechanisms is through dietary fiber and its main fermentation product, butyrate, NF-B signaling (a key transcriptional regulator of inflammatory gene expression) suppressed by lowering IB kinase activity and increasing HDAC inhibition ( Alpha-linolenic acid found in flaxseeds, chia seeds, hemp seeds, and walnuts is used for the production of anti-inflammatory resolvins and protectins through cyclooxygenase and 15-lipoxygenase pathways, which is why it is considered an excellent contributor to the dietary omega-6 to omega-3 fatty acid ratio that deviates from the highly pro-inflammatory values characteristic of typical western diets (Table 2)

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