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Schisandrin B demonstrated anti-inflammatory effects in both in vivo and in vitro colitis models by suppressing the NLRP3 inflammasome and inducing the AMPK/Nrf2 signaling pathway, protecting against ROS-induced mitochondrial damage and alleviating epithelial cell damage via regulation of pyroptosis [478]

Muscle strain and tissue stress models

The lung is the primary target organ of SARS-CoV-2, as the spike protein directly binds to ACE2 receptors expressed on the surface of lung epithelial cells (ECs) 23

3e, f), suggesting that glutathione depletion prevents efficient methylglyoxal detoxification and leads to increased methylglyoxal-associated adducts